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glossary:herpesvirus [2007/09/08 04:59]
Pat O'Connor
glossary:herpesvirus [2012/10/16 14:40] (current)
Line 1: Line 1:
 +One of a family of double-stranded [[DNA]] viruses that cause common infections in humans. These include: herpes, CMV, chickenpox, [[http://​​phpBB2/​viewtopic.php?​t=626|shingles]],​ mono, measles, and [[http://​​phpBB2/​viewtopic.php?​t=641|Kaposi sarcoma]].
 +The herpesviruses may live latently in a person for years or even decades without causing symptoms and then be activated and cause [[disease]]. The human herpesviruses are: 
 +Human herpesvirus 1 (HHV-1) -- The herpes simplex virus type 1 (HSV-1) which causes oral herpes.
 +Human herpesvirus 2 (HHV-2) -- The herpes simplex virus type 2 (HSV-2) which causes genital herpes.
 +Human herpesvirus 3 (HHV-3) -- The cytomegalovirus (CMV).
 +Human herpesvirus 4 (HHV-4) -- The varicella-zoster virus (VZV) which causes chickenpox and shingles.
 +Human herpesvirus 5 (HHV-5) -- The Epstein-Barr virus (EBV) which causes infectious mononucleosis.
 +Human herpesvirus 6 (HHV-6) -- There are two types. Type A is rare, and acquired in adulthood. B is relatively common, usually acquired in childhood, and associated with roseola (measles). ​
 +Human herpesvirus 7: (HHV-7) -- Closely related to HHV-6. Also been associated with roseola (measles). ​
 +Human herpesvirus 8: (HHV-8) -- The virus that causes Kaposi sarcoma. ​
 +The formal name of the herpesvirus family is herpesviridae. All members of this family are double-stranded DNA viruses with large complex genomes that replicate in the nucleus of the [[cell]]. Their genomes contain 60 to 120 genes. Because replication occurs inside the host nucleus, herpesviruses can use the host's transcription machinery and [[DNA]] repair enzymes to support a large genome with complex arrays of both essential or so-called dispensable genes. The essential genes regulate transcription and are needed to construct the virion. The dispensable genes enhance the cellular environment for [[virus]] production, defend the virus from the host [[immune system]] and promote cell to cell spread. The large numbers of dispensable genes are in reality required for a productive in vivo infection. It is only in the laboratory environment of cell culture that they are dispensable.
glossary/herpesvirus.txt ยท Last modified: 2012/10/16 14:40 (external edit)